Publications from 1995-2009

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2013

Shen J, Wang S, Zhang YJ, Wu HC, Kibriya MG, Jasmine F, Ahsan H, Wu DP, Siegel AB, Remotti H, Santella RM. Exploring genome-wide DNA methylation profiles altered in hepatocellular carcinoma using Infinium HumanMethylation 450 BeadChips. Epigenetics. 2013 8(1):34-43 PMID:23208076

Tehranifar P, Wu HC, Fan X, Flom JD, Ferris JS, Cho YH, Gonzalez K, Santella RM, Terry MB. Early life socioeconomic factors and genomic DNA methylation in mid-life. Epigenetics. 2013 8(1):23-7. PMCID:PMC3549876

Barregård L, Moller P, Henriksen T, Mistry V, Koppen G, Rossner P, Sram R, Weimann A, Poulsen H, Nataf R, Andreolli R, Manini P, Marczylo TH, Lam P, Evans MD, Kasai H, Kawai K, Li YS, Sakai K, Singh R, Teichert F, Farmer P, Rozalski R, Gackowski D, Siomek A, Saez G, Cerda C, Broberg K, Lund C, Hossain M, Haghdoost S, Hu CW, Chao MR, Wu KY, Senduran N, Orhan H, Smith RJ, Santella RM, Su Y, Cortez C, Yeh S, Olinski R, Loft S, Cooke MS.Human and methodological sources of variability in the measurement of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine. Antioxid Redox Signal. 18, 2377, 2013 PMCID:PMC3671631

Wu HC, Wang Q, Yang HI, Tsai WY, Chen CJ, Santella RM. Global DNA methylation in a population with aflatoxin B 1 exposure. Epigenetics. 2013 Jul 18;8(9). PMID:23867725

McCullough LE, Santella RM, Cleveland RJ, Millikan RC, Olshan AF, North KE, Bradshaw PT, Eng SM, Terry MB, Shen J, Crew KD, Rossner P Jr, Teitelbaum SL, Neugut AI, Gammon MD. Polymorphisms in DNA repair genes, recreational physical activity and breast cancer risk. Int J Cancer. 2013 Jul 13. doi: 10.1002/ijc.28383.

Wu HC, Delgado-Cruzata L, Machella N, Wang Q, Santella RM, Terry MB. DNA double-strand break repair genotype and phenotype and breast cancer risk within sisters from the New York site of the Breast Cancer Family Registry (BCFR).Cancer Causes Control. 2013 Sep 24. [Epub ahead of print] PMID:24062231

2012

McCullough LE, Santella RM, Cleveland RJ, Bradshaw PT, Millikan RC, North KE, Olshan AF, Eng SM, Ambrosone CB, Ahn J, Steck SE, Teitelbaum SL, Neugut AI, Gammon MD. Polymorphisms in oxidative stress genes, physical activity, and breast cancer risk. Cancer Causes Control. 2012 Dec;23(12):1949-58. doi: 10.1007/s10552-012-0072-1. Epub 2012 Sep 29. PMID:23053794

Wu HC, Santella RM. The role of aflatoxins in hepatocellular carcinoma. Hepat Mon. 2012 Oct;12(10 HCC):e7238. doi: 10.5812/hepatmon. PMCID:PMC3496858

Lumey LH, Terry MB, Delgado-Cruzata L, Liao Y, Wang Q, Susser E, McKeague I, Santella RM. Adult DNA methylation in relation to prenatal nutrition Int J Epidemiol. 41(1):116-23, 2012. PMCID:PMC3304521

Cho YH, Shen J, Gammon MD, Zhang YJ, Wang Q, Gonzalez K, Xu X, Bradshaw PT, Teitelbaum SL, Garbowski G, Hibshoosh H, Neugut AI, Chen J, Santella RM. Prognostic significance of gene-specific promoter hypermethylation in breast cancer patients. Breast Cancer Res Treat. 131(1):197-205, 2012 PMCID:PMC3576848

Flom JD, Ferris JS, Liao Y, Tehranifar P, Belessiotis Richards C, Cho YH, Gonzalez K, Santella RM, Terry MB. Prenatal Smoke Exposure and Genomic DNA Methylation in a Multi-ethnic Urban Birth Cohort. Cancer Epidemiol Biomarkers Prev. 20, 2518-2523, 2011 PMCID:PMC3559183

Delgado-Cruzata L, Hruby GW, Gonzalez K, McKiernan J, Benson MC, Santella RM, Shen J. DNA Methylation Changes Correlate with Gleason Score and Tumor Stage in Prostate Cancer. DNA Cell Biol. 31(2):187-92, 2012 PMCID:PMC3272239

Shen J, Wang S, Zhang YJ, Kappil M, Wu HC, Kibriya MG, Wang Q, Jasmine F, Ahsan H, Lee PH, Yu MW, Chen CJ, Santella RM Genome-wide DNA methylation profiles in hepatocellular carcinoma. Hepatology. 55(6):1799-808, 2012 PMICD:PMC3330167

Xu X, Gammon MD, Hernandez-Vargas H, Herceg Z, Wetmur JG, Teitelbaum SL, Bradshaw PT, Neugut AI, Santella RM, Chen J. DNA Methylation in Peripheral Blood Measured by LUMA is Associated with Breast Cancer in a Population-based Study FASEB J. 2012 26(6):2657-66. PMCID:PMC3360146

Shen J, Hruby GW, McKiernan JM, Gurvich I, Lipsky MJ, Benson MC, Santella RM. Dysregulation of circulating microRNAs and prediction of aggressive prostate cancer. Prostate. 2012 PMCID:PMC3368098

Shen J, Gammon MD, Terry MB, Bradshaw PT, Wang Q, Teitelbaum SL, Neugut AI, Santella RM. Genetic polymorphisms in telomere pathway genes, telomere length and breast cancer survival Breast Cancer Research and Treatment. Breast Cancer Res Treat. 134, 393-400, 2012 PMCID:PMC3579614

Wu HC, Wang Q, Delgado-Cruzata L, Santella RM, Terry MB. Genomic methylation changes over time in peripheral blood mononuclear cell DNA: Differences by assay type and baseline values Cancer Epidemiol Biomarkers Prev.;21(8):1314-8 2012

Wu HC, Wang Q, Yang HI, Tsai WY, Chen CJ, Santella RM. Global DNA methylation levels in white blood cells as a biomarker for hepatocellular carcinoma risk: a nested case-control study Carcinogenesis. 33, 1340-1345, 2012 PMCID:PMC3499052

Wu HC, Wang Q, Delgado-Cruzata L, Flom JD, Perrin M, Liao Y, Ferris JS, Santella RM, Terry MB. Repetitive element DNA methylation levels in white blood cell DNA from sisters discordant for breast cancer from the New York site of the Breast Cancer Family Registry. Carcinogenesis. 33, 1946-1952, 2012

Zhang YJ, Wu HC, Yazici H, Yu MW, Lee PH, Santella RM. Global hypomethylation in hepatocellular carcinoma and its relationship to aflatoxin B(1) exposure. World J Hepatol. 4(5):169-75, 2012. PMCID:PMC3365436

Shen J, Terry MB, Liao Y, Gurvich I, Wang Q, Senie RT, Santella RM. Genetic variation in telomere maintenance genes, telomere length and breast cancer risk.PLoS One. 2012;7(9):e44308. PMCID:PMC3435409

Delgado-Cruzata L, Wu HC, Perrin M, Liao Y, Kappil MA, Ferris JS, Flom JD, Yazici H, Santella RM, Terry MB. Global DNA methylation levels in white blood cell DNA from sisters discordant for breast cancer from the New York site of the Breast Cancer Family Registry. Epigenetics. 2012 7(8):868-74. PMCID:PMC3427282

Shen J, Wang S, Zhang YJ, Kappil MA, Chen Wu H, Kibriya MG, Wang Q, Jasmine F, Ahsan H, Lee PH, Yu MW, Chen CJ, Santella RM. Genome-wide aberrant DNA methylation of microRNA host genes in hepatocellular carcinoma. Epigenetics. 2012 7(11):1230-7. PMID: 22976466

2011

Wu, H-C., Delgado-Cruzata,L, Kappil,M., Flom,J.D., Ferris,J.S.,Liao,Y., Santella,R.M., and Terry, M.B. Global methylation profiles in DNA from different blood cell types. Epigenetics 6, 76-85, 2011 PMCID: PMC3052916.

Wu, H-C., John,E.M., Ferris,J.S., Keegan,T.H., Chung,W.K., Andrulis,I., Delgado-Cruzata,L., Kappil,M., Gonzalez,K. Santella,R.M., and Terry, M.B. Genomic DNA methylation levels in girls with and without a family history of breast cancer. Epigenetics 6, 29-33, 2011. PMCID: PMC3052913

Santella RM, Zhang YJ. Immunologic detection of benzo(a)pyrene-DNA adducts. Methods Mol Biol. 2011;682:271-8 http://www.springerlink.com/content/r63801x25h044414/#section=810998&page=1

Terry MB, Delgado-Cruzata L, Vin-Raviv N, Wu HC, and Santella RM. DNA methylation in white blood cells: Association with risk factors in epidemiologic studies. Epigenetics. 6(7):828-37, 2011. PMC3154425

Xu X, Gammon MD, Jefferson E, Zhang Y, Cho YH, Wetmur JG, Teitelbaum SL, Bradshaw PT, Terry MB, Garbowski G, Hibshoosh H, Neugut AI, Santella RM, Chen J. The influence of one-carbon metabolism on gene promoter methylation in a population-based breast cancer study. Epigenetics. 2011 6(11):1276-83 PMCID:PMC3242810

2010

Shen, J, Gammon, M.D., Wu, H.C., Terry, M.B., Wang, Q., Bradshaw, B.T., Teitelbaum S.L., Neugut, A.I., Santella, R.M. Multiple genetic variants in telomere pathway genes and breast cancer risk. Cancer Epidemiology, Biomarkers & Prevention 19, 219-228, 2010 PMCID: PMC2805470.

Cleveland RJ, Gammon MD, Long CM, Gaudet MM, Eng SM, Teitelbaum SL, Neugut AI, Santella RM., Common genetic variations in the LEP and LEPR genes, obesity and breast cancer incidence and survival. Breast Cancer Res Treat. 120(3):745-52, 2010 http://www.springerlink.com/content/w26173038586142m/

Mordukhovich I, Rossner Jr P Jr, Terry MB, Santella RM, Zhang YJ, Hibshoosh H, Memeo L, Mansukhani M, Long CM, Garbowski G, Agrawal M, Gaudet MM, Steck SE, Sagiv SK, Eng SM, Teitelbaum SL, Neugut AI, Conway-Dorsey K, Gammon MD. Associations between polycyclic aromatic hydrocarbon-related exposures and p53 mutations in breast tumors. Environ Health Perspect. 118, 511-518, 2010. PMCID: PMC2854728.

Hoque A., Ambrosone C.B., Till, C., Goodman, P.J., Tangen, C., Kristal, A., Lucia, S., Wang, Q., Kappil, M., Thompson, I., Hsing, A.W., Parnes, H., Lippman, S.M., Santella, R.M. Serum oxidized protein and prostate cancer risk within the Prostate Cancer Prevention Trial. Cancer Prevention Research 3, 478–483, 2010 PMCID: PMC2853720.

Zipprich, J., Terry, M.B., Brandt-Rauf, P., Freyer, G.A., Liao, Y., Agrawal, M., Gurvich, I., Senie, R. and Santella, R.M. XRCC1 polymorphisms and breast cancer risk from the New York site of the Breast Cancer Family Registry: A family-based case-control study Journal of Carcinogenesis 9, 4, 2010. PMCID: PMC2862506.

Cho, Y.H., Yazici, H., Wu, H-C., Terry, M.B., Gonzalez, K., Qu, M., Dalay, N., Santella, R.M. Aberrant promoter hypermethylation and genomic hypomethylation in tumor, adjacent normal tissues and blood from breast cancer patients. Anticancer Research 30, 2489-2496, 2010 http://ar.iiarjournals.org/content/30/7/2489.lon

Xu X, Gammon MD, Zhang Y, Cho YH, Wetmur JG, Bradshaw PT, Garbowski G, Hibshoosh H, Teitelbaum SL, Neugut AI, Santella RM, Chen J. Gene promoter methylation is associated with increased mortality among women with breast cancer. Breast Cancer Res Treat. 121, 685-692, 2010; PMCID: PMC2869387.

Peng, K-Y., Shih, W-C., Wu, KY., Orhan, H., Istanbullu, N.S., Mistry, V., Farmer, P.B., Sandhu, J., Singh, R., Cortez, C., Su,Y., Santella,R.M., Lambert, P., Smith, R. Towards consensus in the analysis of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine as a non-invasive biomarker of oxidative stress. FASEB Journal 24(4):1249-60, 2010 Dec 4.PMID: 19966135

Ramsey, S. and Santella, R.M The Definition of Life: A Survey of Obstetricians and Neonatologists in New York City Hospitals Regarding Extremely Premature Births. Maternal and Child Health Journal PMC2862506

Grass, D.R., Ross, J.M., Family, F., Barbour, J., Simpson, H. J., Datta, S., Coulibaly, D., Slavkovich, V., Hernandez, J., Chen, Y., Graziano, J., Santella, R., Li, Y., Brandt-Rauf, P.W. and Chillrud, S.N., Airborne Particulate-Metals in the NYC Subway: A Pilot Study to Assess the Potential for Health Impacts, Environmental Research 110(1):1-11, 2010

Mordukhovich I, Rossner Jr P Jr, Terry MB, Santella RM, Zhang YJ, Hibshoosh H, Memeo L, Mansukhani M, Long CM, Garbowski G, Agrawal M, Gaudet MM, Steck SE, Sagiv SK, Eng SM, Teitelbaum SL, Neugut AI, Conway-Dorsey K, Gammon MD. Associations between Polycyclic Aromatic Hydrocarbon-Related Exposures and p53 Mutations in Breast Tumors. Environ Health Perspect. [Epub ahead of print] . PMID: 20064791

2009

Zipprich, J., Terry, M.B., Liao, Y., Agrawal, M., Gurvich, I., Senie, R., and Santella, R.M. Plasma protein carbonyls and breast cancer risk in sisters discordant for breast cancer from the New York site of the Breast Cancer Family Registry. Cancer Research 69(7):2966-72, 2009. PMID: 19339271

Li Y, Marion MJ, Zipprich J, Santella RM, Freyer G, Brandt-Rauf PW. Gene-environment interactions between DNA repair polymorphisms and exposure to the carcinogen vinyl chloride. Biomarkers 14(3):148-155, 2009. PMID: 19274602

Yoon, A.J., Shen, J., Wu, H.C., Angelopoulos, C., Singer, S., Chen, R. and Santella R.M. Expression of Activated Checkpoint Kinase 2 and Histone 2AX in exfoliative oral cells following exposure to ionizing radiation. Radiation Research 17, 771-775, 2009. PMID: 19580484

Xu, X., Gammon, M.D., Zeisel, S.H., Bradshaw, P.T., Wetmur, J.G., Teitelbaum, S.L., Neugut, A.I., Santella, R.M. and Chen,J. High intakes of choline and betaine reduce breast cancer mortality in a population-based Study. FASEB J. 23, 4022-4028, 2009. PMID: 19635752

Yazici, H., Zipprich, J., Peng, T., Akisik, E.Z., Tigli, H., Isin, M., Akisik, E.E., Terry, M.B., Senie, R.T., Li, L., Peng, M., Liu, Z., Santella, R.M. Investigation of the miR16-1 (C>T)+7 substitution in seven different types of cancer from three ethnic groups. Journal of Oncology 2009:827532 PMC2766826

Yazici, H., Terry, M.B., Cho, Y.H., Senie, R.T., Liao, Y., Andrulis, I., and Santella, R.M. Aberrant methylation of RASSF1A in plasma DNA prior to breast cancer diagnosis in the Breast Cancer Family Registry. Cancer Epidemiology, Biomarkers & Prevention 18, 2723-2725, 2009. PMID: 19755643

Shen, J., Gammon, D.G., Terry, M.B., Wang, Q., Bradshaw, P., Teitelbaum, S.L., Neugut, A.I. and Santella, R.M. Telomere length, oxidative damage, antioxidants and breast cancer risk. Int J Cancer. 124(7):1637-43, 2009 PMCID: PMC2727686

Li Y, Long C, Lin G, Marion MJ, Freyer G, Santella RM, Brandt-Rauf PW., Effect of the XRCC1 codon 399 polymorphism on the repair of vinyl chloride metabolite-induced DNA damage. J Carcinog. 2009;8:14.PMID: 19822958

Wu, H.C. Wang, Q., Yang, H.I., Ahsan, H., Tsai, W.Y., Wang, L.Y., Chen, S.Y. Chen, C.J., and Santella, R.M. Aflatoxin B1 exposure, hepatitis B virus infection and hepatocellular carcinoma in Taiwan. Cancer Epidemiology, Biomarkers & Prevention 18, 846-853, 2009. PMID: 19273485

Yeh, C., Santella, R.M., Hsieh, L.L., Sung, F.C., Tang, R. An intron 4 VNTR polymorphism of the endothelial nitric oxide synthase gene is associated with early-onset colorectal cancer. International Journal of Cancer 124(7):1565-71. PMID: 19115208

Sagiv, S.K., Gaudet,M.M., Eng, S.M., Abrahamson, P.E., Shantakumar,S. Teitelbaum,S.L., Bell,P., Thomas, J.A., Neugut,A.I., Santella, R.M., and Gammon, M.D. Polycyclic aromatic hydrocarbon-DNA adducts and survival among women with breast cancer. Environmental Research 109(3):287-291, 2009. PMID: 19181313

McCarty, K.M., Santella, R.M., Steck, S.E., Cleveland, R.J., Ahn, J., Ambrosone, C.B., North,K., Sagiv, S.K., Eng, S.M., Teitelbaum, S.L., Neugut, A.I., and Gammon, M.D. PAH-DNA Adducts, Cigarette Smoking, GST Polymorphisms, and Breast Cancer Risk. Environmental Health Perspectives 117(4):552-528, 2009 PMID: 19440493

Crew, K.D., Gammon, M.D., Steck, S.E., Hershman, D.L., Cremers, S., Dworakowski,E., Shane, E., Terry, M.B., Desai, M., Teitelbaum,S.L., Neugut, A.I., Santella, R.M. Association between plasma 25-hydroxyvitamin D and Breast cancer risk. Cancer Prevention Research 2, 598-604, 2009

Zipprich, J., Terry, M.B., Liao, Y., Agrawal, M., Gurvich, I., Senie, R., and Santella, R.M. Plasma Protein Carbonyls and Breast Cancer Risk in Sisters Discordant for Breast Cancer from the New York Site of the Breast Cancer Family Registry Cancer Research 69(7):2966-72, 2009. PMID: 19339271

Yoon, A.J., Shen, J., Wu, H.C., Angelopoulos, C., Singer, S., Chen, R. and Santella R.M. Expression of Activated Checkpoint Kinase 2 and Histone 2AX in Exfoliative oral cells following exposure to ionizing radiation. Radiation Research 17, 771-775, 2009. PMID: 19580484

Zhang,Y., Wu, H., Shen,J., Li, H., Wang,L., Yu, M-W., Lee, P., Weinstein, I.B. and Santella, R.M. Silencing of Hint1, a novel tumor suppressor gene, by promoter hypermethylation in hepatocellular carcinoma. Cancer Letters 275(2):277-84, 2009. PMID: 19081673

2008

Wu, H.C. Wang, Q., Yang, H.I., Ahsan, H., Tsai, W.Y., Wang, L.Y., Chen, S.Y. Chen, C.J., and Santella, R.M. Urinary 15-F2t-isoprostane, aflatoxin B1 exposure and Hepatitis B virus infection and hepatocellular carcinoma in Taiwan. Carcinogenesis 29, 971-976, 2008.

Mitsumoto, H., Santella, R.M., Hornig, M., Liu, X., Bogdanov, M., Mehrazin, M., Zipprich, J., Wu, H.C., Mahata, J., Kilty, M., Bednarz, K., Bell, D., Gordon, P.H., Naini, A., Beal, M.F., Factor-Litvak, P. Oxidative stress biomarkers in sporadic ALS. Amyotrophic Lateral Sclerosis. Amyotroph Lateral Scler. 9, 177-83, 2008. PMID: 18574762

Gammon, M.D., and Santella. R.M. PAH, Genetic Susceptibility, and Breast Cancer Risk: An Update from the Long Island Breast Cancer Study Project. European Journal of Cancer 44, 636-640, 2008.

Xu, X., Gammon, M.D., Zeisel, S.H., Lee, Y.L. , Wetmur, J.G., Teitelbaum, S.L., Bradshaw, P.T., Neugut, A.I., Santella, R.M., and Chen, J. A., Choline metabolism and risk of breast cancer in a population-based study. The FASEB Journal 6, 2045-52, 2008.

Yeh, C., Barr, R.G., Powell, C.A., Mesia-Vela,S., Wang, Y., Hamade, N.K., Austin, J.H.M. and Santella, R.M. No effect of cigarette smoking dose on oxidized plasma proteins. Environmental Research 106, 219-225, 2008.

Shen J, Gammon MD, Terry MB, Teitelbaum SL, Eng SM, Neugut AI, Santella RM. Xeroderma pigmentosum complementation group C genotypes/diplotypes play no independent or interaction role with polycyclic aromatic hydrocarbons-DNA adducts for breast cancer risk. Eur J Cancer 44, 710-7, 2008.

Hoque, A., Goodman, P., Ambrosone, C.B., Figg, W.D., Price, D.K., Kopp, W., Wu, X., Conroy, J., Lehman, T.A. Santella, R.M. Extraction of DNA from serum for high-throughput genotyping: Findings from pilot studies within the Prostate Cancer Prevention Trial. Urology 71, 967-970, 2008.

Machella, N., Terry, M.B., Zipprich, J., Gurvich, I., Liao, Y., Senie, R.T., Kennedy, D.O. and Santella, R.M. Double strand breaks repair in lymphoblastoid cell lines from sisters discordant for breast cancer. Carcinogenesis 29, 1367-1372, 2008.

Xu, X., Gammon, M.D., Zhang, Y.,, Bestor, T., Zeisel, S.H., Wetmur, J.G., Wallenstein, S., Bradshaw, P.T., Garbowski, G., Teitelbaum, S.L., Neugut, A.I., Santella, R.M., and Chen, J. BRCA1 Promoter methylation is associated with increased mortality among women with breast cancer. Breast Cancer Research and Treatment. 2008 Jun 3.
PMID: 18521744

Terry, M.B., Ferris, J.S., Pilsner, R., Flom, J.D., Tehranifar, P., Santella, R.M., Gamble, M.V. and Susser, E. Genomic DNA methylation among women in a multi-ethnic New York City birth cohort Cancer Epidemiol Biomarkers Prev. 2008 Sep;17(9):2306-10 PMID: 18768498

Golembesky, A.K., Gammon, M.D., North, K.E., Bensen, J.T., Schroeder, J.C., Teitelbaum,S.L., Neugut, A.I., Santella, R.M Peroxisome proliferator-activated receptor-alpha (PPARA) genetic polymorphisms and breast cancer risk: a Long Island ancillary study. Carcinogenesis 29, 1944-1949, 2008. PMID: 18586686

Mahata, J., Argos, M., Verret, W., Kibriya, M.G, Santella, R.M. and Ahsan, H. Effect of selenium and vitamin E supplementation on plasma protein carbonyl levels in patients with arsenic-related skin lesions. Nutr Cancer. 60, 55-60, 2008.

Shen J, Gammon MD, Terry MB, Wang, Q., Brandshaw, P., Teitelbaum SL, Neugut AI, Santella RM. Telomere length, oxidative damage, antioxidants and breast cancer risk Int J Cancer. 2008 PMID: 19089916

2007

Sanyal, M.,Mercan, D., Belander, K., Santella, R.M. DNA adducts in human placenta exposed to ambient environment and cigarette smoke during pregnancy Birth Defects Research Part A: Clinical and Molecular Teratology 79, 289-94, 2007.

Zhang, Y-J., Wu, H-C., Shen, J., Ahsan, H., Tsai, W.Y., Yang, H.I., Wang, L.Y., Chen, S.Y., Chen, C.J. and Santella, R.M. Predicting hepatocellular carcinoma by detection of aberrant promoter methylation in serum DNA. Clinical Cancer Research 13, 2378-2384, 2007.

Sagiv, S.K., Gaudet, M.M., Eng, S.M., Abrahamson, P.E., Shantakumar, S., Teitelbaum, S.L., Britton, J.A., Bell, P., Thomas, J.A., Neugut, A.I., Santella, R.M., Gammon, M.D. Active and passive cigarette smoke and breast cancer survival. Annal. Epi. 17, 385-93, 2007.

Steck, S.E., Gaudet, M.M., Eng, S.M., Britton, J.A., Teitelbaum, S.L., Neugut, A.I., Santella, R.M., and Gammon, M.D. Lifetime versus recent dietary intake of sources of polycyclic aromatic hydrocarbons and heterocyclic amines and breast cancer risk. Epidemiology 18, 373-381, 2007.

Wu, H.C. Wang, W., Wang, L.W., Yang, H.I., Ahsan, H., Tsai, W.Y., Wang, L.Y., Chen, S.Y. Chen, C.J., and Santella, R.M. Polycyclic aromatic hydrocarbon- and aflatoxin-albumin adducts, and Hepatitis B virus infection and hepatocellular carcinoma in Taiwan. Cancer Let. 252, 104-114, 2007

Wu, H.C. Wang, W., Wang, L.W., Yang, H.I., Ahsan, H., Tsai, W.Y., Wang, L.Y., Chen, S.Y. Chen, C.J., and Santella, R.M. Urinary 8-oxodeoxyguanosine, aflatoxin B1 exposure and hepatitis B virus infection and hepatocellular carcinoma in Taiwan. Carcinogenesis 28, 995-999, 2007
Shen, J., Terry, M.B. Gurvich, I., Senie, R.T, and Santella, R.M. Short telomere length and breast cancer risk: a study in sister-pairs. Cancer Research 67, 5538-5544, 2007.
Steck, S.E., Gaudet, M.M., Britton, J.A., Teitelbaum, S.L., Terry, M.B., Neugut, A.I., Santella, R.M., and Gammon, M.D. Interactions among GSTM1, GSTT1 and GSTP1 polymorphisms, cruciferous vegetable intake and breast cancer risk. Carcinogenesis 28, 1954-1959, 2007.

Xu, X., Gammon, M.D., Rao, M., Wetmur, J.G., Teitelbaum, S.L., Neugut, A.I., Santella, R.M., Chen, J. A functional 19bp deletion polymorphism of dihydrofolate reductase (DHFR) and risk of breast cancer among multivitamin users. Am J Clin Nutr 85, 1098-1102, 2007.

Wang, L., Zhang, Y.J., Li, H., Xu,Z., Santella, R.M., and Weinstein, I.B. Hint1 inhibits growth and activator protein-1 activity in human colon cancer cells Cancer Res. 67, 4700-4708, 2007

Terry, M.T., Gammon, M.D., Zhang, F.F., Vaughan, T.L., Chow, W.H., Risch, H.A., Schoenberg, J.B., Mayne, S.T., Stanford, J.L., West, A.B., Rotterdam, H., Blot, W.J., Fraumeni, JF., and Santella, R.M. Alcohol intake, metabolism and risk of esophageal and gastric adenocarcinomas. Cancer Causes & Control 18, 1039-46, 2007.

Chen, Y., Santella, R.M., Kibriya, M., Wang, Q., Kappil, M., Verret, W.J., Graziano, J.H., and Ahsan, A. Association between arsenic exposure from drinking water and plasma levels of soluble cell adhesion molecules. Environmental Health Perspectives, 115,1415-20, 2007.

Peng, T., Li, L.Q., Peng, M.H.m Liu, Z.M., Liu, T.W., Guo,Y., Xiao, K.Y., Qin, Z., Ye, X.P., Mo, X.S., Yan, L.N., Lee, B.L., Shen, H.M., Tamae,K. Wang, L.W., Wang, Q., Khan, K.M., Wang, K, Liang, R. Wei, Z, Kasai, H., Ong, C.N. and Santella, R.M. Evaluation of oxidative stress in a group of adolescents exposed to a high-level of aflatoxin B1—a multi-center and multi-biomarker study. Carcinogenesis 28, 2347-2354, 2007.

Crew, K.D., Gammon, M.D., Terry, M.B., Zhang, F.F., Agrawal, M., Eng, S.M., Sagiv, S.K., Teitelbaum,S.L., Neugut, A.I., Santella, R.M. Genetic polymorphisms in the apoptosis-associated genes FAS and FASL and breast cancer risk. Carcinogenesis 28, 2548-2551, 2007.

Rossner Jr., P., Gammon, M.D., Terry, M.B., Agrawal, M., Ferris, J.S., Zhang, F.F., Teitelbaum, S.T., Eng, S.M., Gaudet, M.M., Neugut A., Santella R.M. Plasma protein carbonyl levels and breast cancer risk. Journal of Cellular and Molecular Medicine 11, 1138-1148, 2007.

Crew, K.D., Gammon, M.D., Terry, M.B., Zhang, F.F., Agrawal, M., Eng, S.M., Sagiv, S.K., Teitelbaum,S.L., Neugut, A.I., Santella, R.M. Polymorphisms in nucleotide excision repair genes, polycyclic aromatic hydrocarbon-DNA adducts, and breast cancer risk Cancer Epidemiol Biomarkers Prev.16, 2033-41, 2007.

Zhang, Y.J., Shen, J., Yu, M.W., Lee, P.H. and Santella, R.M. Telomere length in hepatocellular carcinoma and paired adjacent non-tumor tissues by quantitative PCR. Cancer Investigation 25, 668-677, 2007.

Yoon, A.J., Shen, J., Santella, R.M., Zegarelli, D.J., Chen, R., and Weinstein, I.B. Activated checkpoint kinase 2 expression and risk for oral squamous cell carcinoma. Cancer Epidemiology Biomarkers & Prevention 16, 2768-3772, 2007.

2006

Santella RM. Approaches to DNA/RNA Extraction and whole genome amplification. Cancer Epidemiology, Biomarkers & Prevention. 15(9):1585-7, 2006

Shen, J.Terry, M.B., Gammon, M.D., Gaudet, M.M., Teitelbaum, S.L., Eng, S.M., Sagiv, S.K., Neugut, A. I., and Santella, R.M. IGHMBP2 Thr671Ala polymorphism might be a modifier for the effects of cigarette smoking and PAH-DNA adducts to breast cancer risk. Breast Cancer Research and Treatment 99. 1-7, 2006.

Zhang, YJ., Rossner, P., Chen, Y., Agrawal, M., Wang, Q., Wang, L., Ahsan, H., Yu, MW., Lee, PH., Sanella, R.M. Aflatoxin B1 and polycyclic aromatic hydrocarbon adducts, p53 mutations and p16 methylation in liver tissue and plasma of hepatocellular carcinoma patients. Int. J. Cancer 119, 985-991, 2006.

Perera FP. Tang D. Brandt-Rauf P. Santella RM. Mooney LV. Tu YH. Bendkowska I. Bell DA. Lack of associations among cancer and albumin adducts, ras p21 oncoprotein levels, and CYP1A1, CYP2D6, NAT1, and NAT2 in a nested case-control study of lung cancer within the physicians' health study. Cancer Epidemiology, Biomarkers & Prevention. 15(7):1417-9, 2006.

Rossner, P., Terry, M.B., Gammon, M.D., Zhang, F.F., Teitelbaum, S.L., Eng, S.M., Sagiv, S.K., Gaudet, M.M., Neugut, A. I., and Santella, R.M. OGG1 polymorphism and breast cancer risk. Cancer Epi. Biomarkers & Prevention 15, 811-5, 2006.

Rossner, P., Gammon, M.D., Terry, M.B., Agrawal, M., Zhang, F.F., Teitelbaum, S.L., Eng, S.M., Gaudet, M.M., Neugut, A. I., and Santella, R.M. Relationship between urinary 15-F2t-isoprostane and 8-oxodeoxyguanosine levels and breast cancer risk. Cancer Epi. Biomarkers & Prevention 15, 639-44, 2006.

Li, H., Zhang, Y., Santella, R.M. and Weinstein, I.B. Hint1 is a haplo-insufficient tumor suppressor in mice. Oncogene 25, 713-721, 2006.

Louis, E.D., Factor-Litvak, P., Parides, M., Andrews, L., Santella, R.M., and Wolff, M.S. Organochlorine pesticide exposure in essential tremor: A case-control study using biological and occupational exposure assessments. Neurotoxicology 27(4):579-86, 2006.

Beyea, J., Hatch, M., Stellman, S.D., Santella, R.M., Teitelbaum, S.L., Prokopczyk, B., Camann, D., Gammon, M.D. Validation and calibration of a model used to reconstruct historical exposure to polycyclic aromatic hydrocarbons for use in epidemiologic studies. Environmental Health Perspectives 114, 1053-1058, 2006.

Terry, M.B., Gammon, M.D., Zhang, F.F., Knight, J.A., Wang, Q., Britton, J.A., Teitelbaum, S.L., Neugut, A.I. and Santella, R.M. ADH3 genotype, alcohol intake, and breast cancer risk. Carcinogenesis 27, 840-847, 2006.

Li, Y., Marion, M.J., Zipprich, J., Freyer, G., Santella, R.M., Kanki, C., Brandt-Rauf, P.W. The role of XRCC1 polymorphisms in base excision repair of etheno-DNA adducts in French vinyl chloride workers. Int. J. Occup. Environ. Health 19, 45-52, 2006.

Shen, J., Desai, M., Agrawal, M., Kennedy, D., Senie, R.S., Santella, R.M. and Terry, M.B. Polymorphisms in nucleotide excision repair genes and DNA repair capacity in sisters discordant for breast cancer Cancer Epi., Biomarkers & Prevention 15,1614-1619,2006.

2005

Machella, N., Regoli, F., Santella, R.M. Immunofluorescent detection of 8-oxo-dG and PAH bulky adducts in fish liver and mussel digestive gland. Aquatic Toxicology 71 335-343, 2005.

Wolff, M.S., Teitelbaum, S.L., Lioy, P.J., Santella, R.M., Wang, R.Y., Jones, R.L., Caldwell, K.L., Sjodin, A., Turner, W.E., Li, W., Georgopoulos, P., and Berkowitz, G.S. Exposures among pregnant women near the World Trade Center site on 11 September 2001. Environ. Health Perspectives 113, 739-748, 2005.

Ahn, J., Gammon, M.D., Santella, R.M., Gaudet, M.M., Britton, J.A., Teitelbaum, S.L., Terry, M.B., Nowell, S., Davis, W., Garza, C., Neugut, A.I., Ambrosone, C.B. Associations between breast cancer risk and the endogenous antioxidant catalase (CAT), fruit and vegetable consumption, and supplement use. Amer. J. Epi. 162, 1-10, 2005.

Paracchini, V., Chang, S.S., Santella, R.M., Garte,S., Pedotti, P., Taioli, E. GSTM1 deletion modifies the levels of polycyclic aromtic hydrocarbon-DNA adducts in human sperm Mutation Res. 586, 97-101, 2005.

Shen, J.Terry, M.B., Gammon, M.D., Zhang, F.F., Teitelbaum, S.L., Eng, S.M., Sagiv, S.K., Gaudet, M.M., Neugut, A. I., and Santella, R.M. MGMT genotype, haplotype and susceptibility to breast cancer –– evidence from a population-based case-control study. Carcinogenesis 12, 2131-2137, 2005

Shantakumar, S., Gammon, M.D., Eng,S.M., Sagiv,S.K., Gaudet,M.M., Teitelbaum,S.T., Britton,J.A., Terry,M.B., Paykin,A., Young, T.L. Wang,L.W., Wang,Q., Stellman,S.D., Beyea,J., Hatch,M., Camann,D., Prokopczyk,B., Kabat,G.C., Levin,B., Neugut,A.I. and Santella, R.M. Residential environmental exposures and other characteristics associated with detectable PAH-DNA adducts in peripheral mononuclear cells in a population-based sample of adult females. J. Expo. Anal. Environ. Epi. 65, 1606-14, 2005.

Shen, J.,Terry, M.B., Gammon, M.D., Wang, L.W., Wang,Q., Zhang, F.F., Teitelbaum, S.L., Neugut, A., Santella, R.M. Genetic polymorphisms in the DNA repair gene XRCC1 and, interaction with PAH-DNA adducts on breast cancer risk Cancer Epi. Biomarkers & Prevention 14, 336-42, 2005

Zhang, Y.J., Chen, Y., Ahsan,H., Lunn, RM., Chen, S.Y., Lee,P.H., Chen, C.J. and Santella, R.M. Silencing of glutathione S-transferase P1 by promoter hypermethylation and its relationship to environmental chemical carcinogens in hepatocellular carcinoma. Cancer Letters 221, 135-143, 2005.

Ahsan, H., Whittemore, A.S., Chen, Y., Senie,R.T., Hamilton, S.P., Wang, Q., Gurvich, I., Santella,R.M. Variants in estrogen-biosynthesis genes CYP17 and Cyp 19 and breast cancer risk: a family-based genetic association study. Breast Cancer Research 7, R71-R81, 2005.

Kennedy, D.O., Agrawal, M., Shen, J., Terry, M.B., Zhang, F.F., Senie, R.T., Motykiewicz, G., and Santella, R.M. DNA repair capacity of lymphoblastoid cell lines from sisters discordant for breast cancer. Journal of the National Cancer Institute 97, 127-132, 2005.

Kelley, M.J., Glaser, E.M., Herndon, J.E, Becker, F., Zhang, Y-J., Santella, R.M., Carmella, S.G., Hecht, S.S., Gallot, L., Schilder,L., Crowell, J.A., Perloff, M., Folz, R.J., and Bergan, R.C. Safety and efficacy of weekly oral oltipraz in chronic smokers. Cancer Epidemiology, Biomarkers & Prevention Cancer Epi. Biiomarkers & Prevention 14 892-899, 2005.

Chen, J., Gammon, M.D., Chan, W., Palomeque, C., Wetmur, J.G., Kabat, G.C., Teitelbaum, S.T., Britton, J.A., Terry, M.B., Neugut, A.I., and Santella, R.M. One-Carbon metabolism, MTHFR polymorphisms and risk of breast cancer. Cancer Research 65,1606-1614, 2005.

Kristal, A.R., King, I.B., Albanes, D., Pollak, M.N., Stanzyk, F.Z., Santella, R.M., and Hoque, A. Centralized blood processing for the Selenium and Vitamin E Cancer Prevention Trial: Effect of delayed processing on carotenoids, tocopherols, insulin-like growth factor-1, insulin-like growth factor binding protein3, steroid hormones and lymphocyte viability. Cancer Epi. Biomarkers & Prevention 14, 727-730, 2005.

Machella, N., Regoli, F., Santella, R.M. Immunofluorescent detection of 8-oxo-dG and PAH bulky adducts in fish liver and mussel digestive gland. Aquatic Toxicology 71 335-343, 2005.

2004

Gammon, M.D., Eng, S.M., Teitelbaum, S.L., Britton, J.A., Kabat, G.C., Hatch, M., Paykin, A.B., Neugut, A.I. and Santella, R. M. Environmental Tobacco Smoke and Breast Cancer Incidence. Environmental Research 92, 176-185, 2004.

Chen, S.Y., Liu, T.Y., Shun, C.T., Wu, M.S., Lu, T.H., Lin, J.T., Sheu, J.C., Santella, R.M. and Chen, C.J. Modification effects of GSTM1, GSTT1 and CYP2E1 polymorphisms on associations between raw salted food and incomplete intestinal metaplasia in a high-risk area of stomach cancer. Int. J. Cancer 108, 606-612, 2004.

Machella, N., Regoli, F., Cambria, A., and Santella, R.M. Application of an immunoperoxidase staining method for detection of 7,8-dihydro-8-oxodeoxyguanosine as a biomarker of chemical-induced oxidative stress in marine organisms. Aquatic Toxicology 67, 23-32,2004.

Terry, M.B., Gammon, M.D., Eng, S., Paykin, A., Wang, Q., Hayes, S., Neugut, A., Teitelbaum, S.L., and Santella, R.M. Polymorphism in the DNA repair gene XPD, polycyclic aromatic hydrocarbon-DNA adducts, cigarette smoking and breast cancer risk. Cancer Epi. Biomarkers & Prevention 13, 2053-2058, 2004.

Machella, N., Regoli, F., Cambria, A., and Santella, R.M. Oxidative damage to DNA:an immunohistochemical approach for detection of 7,8-dihydro-8-oxodeoxyguanosine in marine organisms. Marine Environmental Res. 58, 725-729, 2004.

2003

Zhang, Y.J., Chen, Y., Ahsan, H., Lunn, R.M., Lee, P.H., Chen,C.J., and Santella, R.M. Inactivation of the DNA repair gene 0⁶-Methylguanine-DNA methyltransferase by promoter hypermethylation and its relationship to aflatoxin B₁- DNA adducts and p53 mutation in hepatocellular carcinoma Int. J. Cancer 103, 440-444, 2003.

Singh, R., McEwan, M., Lamb, J.H., Santella, R.M. and Farmer, P.B. An improved liquid chromatography-mass spectrometry/mass spectrometry method for the determination of 8-hydroxy-2'-deoxyguanosine in DNA samples using immunoaffinity column purification. Rapid Communications in Mass Spectrometry 17; 126-134, 2003.

Gaspari. L., Chang, S-S., Santella, R.M., Garte, S., Pedotti, P. and Taioli, E. Polycyclic aromatic hydrocarbon-DNA adducts in human sperm as a marker of DNA damage and infertility. Mutation Research, Genetic Toxicology and Environmental Mutagenesis 535, 155-160, 2003.

Krebs, C., Koestner, W., Nissen, M., Welge, V., Parusel,I., Malavasi, F., Leiter, E., Santella, R.M., Haag, F. and Koch-Nolte,F. Flow cytometric and immunoblot assays for cell surface ADP-ribosylation using a monoclonal antibody specific for ethenoadenosine Analytical Biochem 314: 108-115, 2003.

Faraglia, B., Chen,S.Y., Gammon, M.D., Zhang, Y.J., Teitelbaum, S., Neugut, A.I., Ahsan, H., Garbowski, G.C., Hibshoosh, H., Lin, D., Kadlubar, F.F., and Santella, R.M. Evaluation of 4-aminobiphenyl-DNA adducts in human breast cancer: The influence of tobacco smoke Carcinogenesis 24, 719-725, 2003.

Gammon, M.D. and Santella, R.M. Correspondence re:Gammon et. al., Environmental toxins and breast cancer on Long Island. I. Polycyclic aromatic hydrocarbon DNA adducts. Cancer Epidemiology, Biomarkers & Prevention 11, 677-685, 2003.

Ahsan, H., Chen, Y., Wang, Q., Slovkovich, V., Graziano, J.H., and Santella, R.M. DNA Repair Gene XPD and Susceptibility to Arsenic-induced Hyperkeratosis. Toxicology Letters 143, 123-131, 2003.

Weiserbs, K.F., Jacobson, J.S., Begg, M.D., Wang, L.W., Wang, Q., Agrawal, M., Norkus, E.P., Young, T.L. and Santella, R.M. A cross-sectional study of polycyclic aromatic hydrocarbon-DNA adducts and polymorphism of glutathione S-transferases among heavy smokers by race/ethnicity. Biomarkers 8, 142-155, 2003.

Rahman, M.H., Arslan, M.I., Chen, Y., Ali, S., Parvin, T., Wang, L.W., Santella, R.M., Ahsan, H. Polycyclic aromatic hydrocarbon-DNA adducts among rickshaw drivers in Dhaka City, Bangladesh. Int. Arch. Occup. Environ. Health 2003.

2002

Carlson, N., Lechago, J., Richter, J., Sampliner, R.E., Peterson, L., Santella, R.M., Goldblum, J., Falk, G., Ertan, A. and Younes,M. Acid suppression therapy (AST) may not alter malignant progression in Barrett's metaplasia (BM) showing p53 protein accumulation Amer. J. Gastroenterlogy 97, 340-345, 2002.

Perera, F.P., Hemminki, K., Jedyrychowski, W., Whyatt, R., Hsu, Y., Campbell, R. Santella,R.M., O'Neill, P. DNA Damage from environmental carcinogens is associated with somatic gene mutation in newborns. Cancer Epi. Biomarkers & Prevent. 11, 1134-1137, 2002.

Kessel, M., Liu, S.X., Xu, A., Santella, R. and Hei, T.K. Arsenic induces oxidative DNA damage in mammalian cells Molecular and Cellular Biochemistry 234/235 301-308, 2002.

Zhang, Y.J., Ahsan, H., Chen, Y., Lunn, R., Wang, L.Y., Chen, S.Y., Lee, P.H., Chen, C.J. and Santella, R.M. High frequency of promoter hypermethylation of the RASSF1A and p16 genes and its relationship to aflatoxin B1-DNA adduct levels in human hepatocellular carcinoma Molecular Carcinogenesis35, 85-92, 2002.

Zhang, Y.J., Chen, Y., Ahsan, H., Lunn, R.M., Lee, P.H., Chen,C.J., and Santella, R.M. Inactivation of the DNA repair gene 06-Methylguanine-DNA methyltransferase by promoter hypermethylation and its relationship to aflatoxin B1- DNA adducts and p53 mutation in hepatocellular carcinoma Int. J. Cancer.

Sun, C.A., Wu, D.M., Wang, L.Y., Chen, C.J., You, S.L. and Santella, R.M. Determinants of formation of aflatoxin-albmin adducts: a seven-township study in Taiwan British J Cancer 87: 966-970, 2002

Motykiewicz, G., Faraglia, B. Wand, L., Terry, M.B., Senie, R.T. and Santella, R.M. Removal of benzo(a)pyrene diol epoxide (BPDE)-DNA adducts as a measure of DNA-repair capacity in lymphoblastoid cell lines from sisters discordant for breast cancer. Environmental and Molecular Mutagenesis 40, 93-100, 2002.

Gammon, M.D., Santella, R.M., Neugut, A.I., Eng, S.M., Paykin, A., Teitelbaum, S.L., Levin, B., Terry, M.B., Young, T.L., Wang, L., Wang, Q., Britton, J.A., Wolff, M.S., Stellman, S.D., Hatch, M., Kabat, G., Senie, R., Garbowski, G., Maffeo, C., Montalvan, P., Kemeny, M., Citron, M., Schnabel, F., Schuss, A., Vinceguerra, V. PAH-DNA adducts and the risk of breast cancer among women on Long Island. Cancer Epi. Biomarkers & Prevention, 11, 677-685, 2002.

Gammon, M.D., Wolff, M.S., Neugut, A. I., Eng, S.M., Teitelbaum, S.L., Britton, J.A., Terry, M.B.,Levin, B., Stellman, S.D., Kabat, G., Hatch, M., Senie, R., Berkowitz, G., Bradlow, H.L., Garbowski, G., Maffeo, C., Montalvan, P. Kemeny, M., Citron. M., Schnabel, F., Schuss, A., Hajdu, S., Vinceguerra, V. , Niguidula, N., Ireland, K. and Santella, R.M.,Environmental Toxins and breast cancer on Long Island. II. Organochlorine compound levels in blood. Cancer Epi. Biomarkers & Prevention 11, 686-691, 2002.

Gammon, M.D., Neugut, A.I., Santella, R.M., Teitelbaum, S.L., Britton J.A., Terry, M.B., Eng, S.M., Wolff, M.S., Stellman, S.D., Kabat, G., Levin, B., Bradlow, H.L., Hatch, M., Beyea, J., Camann, D., Trent, M., Senie, R., Maffeo, C., Montalvan, P., Garbowski, G., Berkowitz, G., Kemeny, M., Citron, M., Schnabel, F., Schuss, A., Hajdu, S., Vinceguerra, V. The Long Island Breast Cancer Study Project: description of a multi-institutional collaboration to identify environmental risk factors for breast cancer. Breast Cancer Research and Treatment 74, 235-254, 2002.

Zhang, Y.J., Chang, S.Y., Hsu, T.M., and Santella, R.M. Immunohistochemical detection of malondialdehyde-DNA adducts in human oral mucosa cells. Carcinogenesis, 23, 207-211, 2002.

Chen, S.Y., Wang, L.Y., Lunn, R.M., Tsai, W.Y., Lee, P.H., Lee, C.S., Ahsan, H., Zhang, Y.J., Chen, C.J., Santella, R.M. Polycyclic aromatic hydrocarbon-DNA adducts in liver tissues of hepatocellular carcinoma patients and controls. Int. J. Cancer 99, 14-21, 2002.

Zhang, Y.J., Chen, S.Y., Chen, C.J., Santella, R.M. Polymorphism of the cyclin D1 gene in hepatocellular carcinoma. Molecular Carcinogenesis 33, 125-129, 2002.

2001

Chen, S.Y., Chen, C.J., Chou, S.R., Hsieh, L.L., Wang, L.Y., Tsai, W.Y., Ahsan, H., Santella, R.M. Association of aflatoxin B1-albumin adduct levels with hepatitis B surface antigen status among adolescents in Taiwan. Cancer Epi. Biomarkers & Prevention 10, 1223-1226, 2001.

Ahsan, H., Wang, L.Y., Chen, C.J., Tsai, W.Y., Santella, R.M. Intraindividual variability in aflatoxin-albumin adduct levels and effects of hepatitis B and C virus infection and glutathione S-transferase M1 and T1 genotype. Envir. Health Persp. 109, 833-837, 2001.

Sun, C.A., Wang, L.Y., Chen, C.J., Lu, S.N., You, S.L., Wang, L.W., Wang, Q., Wu, D.M., Santella, R.M. Genetic polymorphisms of glutathione S-transferase M1 and T1 associated with susceptibility to aflatoxin-related hepatocarcinogenesis among chronic hepatitis B carriers: A nested case-control study in Taiwan. Carcinogenesis 22, 1289-1294, 2001.

Motykiewicz, G., Malusecka, E., Michalsecka, E., Kalinowska, E., Wloch, J., Butkiewicz, D., Mazurek, A., Lange, D., Perera, F.P., Santella, R.M. Immunoperoxidase detection of polycylic aromatic hydrocarbon-DNA adducts in breast tissue sections. Cancer Detection and Prevention 25, 328-335, 2001.

2000

Simpson, C.D., Wu, M.T., Christiani, D.C., Santella, R.M., Carmella, S.G. and Hecht, S.S. Determination of r-7,t-8,9,c-10-tetrahydrozy-7,8,9,10-tetrahydrobenzo[a]pyrene in human urine by gas chromatography-negative ion chemical ionization-mass spectrometry. Chem. Res. Toxicol. 13, 271-280, 2000.

Chen, S.Y., Chen, C.J., Tsai, W.Y., Ahsan, H., Liu, T.Y., Lin, J.T. Santella, R.M. Associations of plasma aflatoxin B1-albumin adducts level with plasma selenium level and genetic polymorphisms of glutathione S-transferase M1 and T1. Nutrition and Cancer 38, 179-185, 2000.

Banerjee, R., Caruccio, L., Zhang, Y.J., McKercher, S., Santella, R.M. Effects of carcinogen induced transcription factors on the activation of hepatitis B virus expression in human hepatoblastoma HEPG2 cells and its implication on hepatocellular carcinomas. Hepatology 2000.

Zhang, Y.J., Chen, S.Y., Tsai, W.Y., Ahsan, H., Lunn, R.M., Wang, L.Y., Chen,C.J. and Santella, R.M. Expression of cytochrome P450 1A1/2 and 3A4 in liver tissues of hepatocellular carcinoma cases and controls from Taiwan and their relationship to Hepatitis B virus and aflatoxin B1- and 4-aminobiphenyl-DNA adducts. Biomarkers 2000.

Santella, R.M., Gammon, M., Motykiewicz, G., Young T.L., Zhang,Y.J., Hayes, S.C., Terry, M.B., Schoenberg, J.A., Brinton, L.A., Bose, S., Teitelbaum, S.L., Hibshoosh, H. Immunohistochemical analysis of polycyclic aromatic hydrocarbon-DNA adducts in breast tumor tissue. Cancer Letters 154, 143-149, 2000.

Poirier, M.C., Santella, R.M. and Weston, A. Carcinogen macromolecular adducts and their measurement. Carcinogenesis 21, 353-359, 2000.

Whyatt,R.M., Perera, F.P., Jedrychowski, W., Santella, R.M., Garte, S., Bell,D.A. Association between polycyclic aromatic hydrocarbon-DNA adduct levels in maternal and newborn white blood cells and glutathione S-transferase P1 and CYP1A1 polymorphisms. Cancer Epi, Biomarkers, & Prevention 8, 207-212, 2000.

1999

Fontana, R.J., Lown, K.S., Paine, M.F., Fortlage, L., Santella, R.M., Felton, J.S., Knize, M.G., Greenberg, A., Watkins, P.B. Effects of a chargrilled meat diet on expression of CYP3A4, CYP1A, and P-glycoprotein levels in healthy voluneteers. Gastroenterology 11 789-98, 1999.

Xu, A., Wu, L.J., Santella, R.M. and Hei, T. Role of oxyradiacals in mutagenicity and DNA damage induced by crocidolite asbestos in mammalian cells Cancer Res. 59, 5922-5926, 1999.

Yao, Y., Slosberg, E.D., Wang, L., Hibshoosh, H., Zhang, Y.J., Xing, W.Q., Santella, R.M., and Weinstein, I.B. Increased susceptibility to carcinogen-induced mammary tumors in MMTV-Cdc25B transgenic mice Oncogene 18, 5159-5166, 1999.

Northridge, M.E., Yankura, J., Kinney, P.L., Santella, R.M., Shepard, P., Riojas, Y., Aggarwal, M., Strickland, P., and the Earth Crew Diesel exhaust exposure among adolescents in Harlem: a community-driven study. Amer. J. Public Health 89, 998-1002, 1999.

Santella, R.M. Immunologic methods for detection of DNA damage in humans. Cancer Epi, Biomarkers & Prevention 8, 733-739, 1999.

Yu, M.W., Chiu, Y.H., Yang, S.Y., Santella, R.M., Chern, H.D., Liaw,Y.F., Chen, C.J. Cytochrome P4501A1 genetic polymorphisms and risk of hepatocellular carcinoma among chronic hepatitis B carriers Brit. J. Cancer 80, 598-603, 1999.

Hoque, A., Patt, Y.Z., Yoffe, B., Groopman, J.D., Greenblatt, M.S., Zhang, Y.J., and Santella, R.M. Does aflatoxin B1 play a role in the etiology of hepatocellular carcinoma (HCC) in the United States (U.S.)? Nutrition and Cancer 35, 27-33, 1999.

Romano, G., Sgambato, A., Boninsegna, A., Flamini, G., Curigliano, G., Yang, Q., LaGioia, V., Signorelli, C., Ferro, A., Capelli, G., Santella, R.M., and Cittadini, A. Evaluation of polycyclic aromatic hydrocarbon-DNA adducts in exfoliated oral cells by an immunohistochemical assay. Cancer Epi. Biomarkers & Prevention 8, 91-96, 1999.

Zhao,J.F., Zhang,Y.J., Kubilus, J., Jin, X.H., Santella, R.M., Athar, M., Wang, Z.Y., Bickers, D.R. Reconstituted 3-dimenstional human skin as a novel in vitro model for studies of carcinogenesis Biochem. Biophys. Res. Commun. 254 49-53, 1999.

Calderon-Garciduenas, L., Wang, L.W., Zhang, Y.J., Rodriguez-Alcaraz, A., Osnaya, N., Villarreal-Calderon, A., Santella, R.M. 8-Hydroxy-2'deoxyguanosine, a major mutagenic oxidative DNA lesion and DNA strand breaks in nasal respiratory epithelium of children exposed to urban pollution. Environ. Health Persp. 107, 469-474, 1999.

Yu, M.W., Chiu, Y.H., Chiang, Y.C., Chen, C.H., Lee, T.H., Santella, R.M., Chern, H.D., Liaw, Y.F., and Chen, C.J. Plasma carotenoids, glutatione S-transferase M1 and T1 genetic polymorphisms and risk of hepatocellular carcinoma: independent and interactive effects. Amer. J. Epi.149, 621-629, 1999.

Yao, Y.J., Zhang, H., Lee, P.K., Ahsan, H., Chen,C.J., Lee, P.O., Peacocke, M., Santella, R.M., and Tsou,H.C. PTEN/MMAC1 mutations in hepatocellular carcinomas. Oncogene 18, 3181-3185, 1999.

1998

Tang, D.L., Rundle, A., Warburton, D., Santella, R.M., Tsai, W.Y., Chiamprasert, S., Hsu, Y.Z., and Perera, F.P. Associations between both genetic and environmental biomarkers and lung cancer: evidence of a greater risk of lung cancer in women smokers. Carcinogenesis 19, 1949-1954, 1998.

Begemann, M., Kashimawo, S.A., Lunn, R.M., Delohery, T., Choi, Y.J.A., Kim, S., Heitjan, D.F., Santella, R.M., Schiff, P.B., Bruce, J.N., and Weinstein, I.B. Growth inhibition induced by Ro31-8220 and calphostin C in human glioblastoma cell lines is associated with apoptosis and inhibition of CDC2 kinase. Anticancer Res. 18, 3139-3152, 1998.

Zhang, Y.J., Weksler, B.B., Wang, L.Y., Schwartz, J. and Santella, R.M. Immunohistochemical detection of polycyclic aromatic hydrocarbon-DNA damage in human blood vessels of smokers and non-smokers Atherosclerosis 140, 325-331, 1998.

Motykiewicz, G., Michalska, J., Pendzich, J., Malusecka, E., Strozyk,M., Kalinowska, E., Butkiewicz, D., Mielzynska, D., Midro, A., Santella, R.M., Chorazy, M. A molecular epidemiology study in women from Upper Silesia, Poland. Toxicology Let. 96,97, 195-202, 1998.

Whyatt, R.M., Bell, D.A., Jedrychowski, W., Santella, R.M., Garte, S.J., Cosma,G., Manchester, D.K., Young, T.L., Cooper, T.B., Ottman, R., Perera, F.P. Polycyclic aromatic hydrocarbon-DNA adducts in human placenta and modulation by CYP1A1 induction and genotype. Carcinogenesis 19, 1389-1392, 1998.

Sgambato, A., Zhang, Y.J., Ciaparrone, M., Soh, J.W., Cittadini, A., Santella, R.M., and Weinstein, I.B. Overexpression of p27Kip1 inhibits the growth of both normal and transformed human mammary epithelial cells. Cancer Res. 58, 3448-3454, 1998.

Whyatt, R.M., Santella, R.M., Jedrychowski, W., Garte, S.J., Bell, D.A., Ottman, R., Gladek-Yarborough, A., Cosma, G., Young, T.L., Cooper, T.B., Randall, M.C., Manchester, D.K., Perera, F.P. Relationship between ambient air pollution and DNA damage in Polish mothers and newborns Envir. Health Perspect. 106, 821-826, 1998.

Flamini, G., Romano, Gianpiero, R., Curigliano, G., Chiominto, A., Capelli, G., Boninsegna, A., Signorelli, C., Ventura, L., Santella, R.M., Sgambato, A., and Cittadini, A. 4-Aminobiphenyl-DNA adducts in laryngeal tissue and smoking habits: an immunohistochemical study. Carcinogenesis 19, 353-357, 1998.

Perera, F.P., Whyatt, R.M., Jedrychowski, W., Rauh, V., Manchester, D., Santella, R.M., and Ottman,R. Recent developments in molecular epidemiology - A study of the effects of environmental polycyclic aromatic hydrocarbons on birth outcomes in Poland Amer J. Epi. 147, 309-314, 1998.

Wang, L-Y, Chen, C.J., Zhang,Y-J., Tsai W-Y., Lee P-H., Feitelson, M.A., Lee, C-S., Santella, R.M. 4-Aminobiphenyl-DNA damage in liver tissue of hepatocellular carcinoma patients and controls. Amer, J. Epi. 147, 315-323, 1998.

1997

Dickey, C., Santella, R.M., Hattis, D., Tang, D., Hsu, Y., Cooper, T., Young, T.L., and Perera, F.P. Variability in PAH-DNA adduct measurements in peripheral mononuclear cells: implications for quantitative cancer risk assessment. Risk Analysis 17, 649-656, 1997.

Romano, G., Mancini, R., Fedele, P., Curigliano, G., Flamini, G., Giovagnoli, M.R., Malara, N., Boninsegna, A., Vecchione, A, Santella, R.M., Cittadini, A. Immunohistochemical analysis of 4-aminobiphenyl-DNA adducts in oral mucosal cells of smokers and nonsmokers. Anticancer Research 17, 2827-2830, 1997.

Yu, M.W., Lien, H.P., Chiu, Y.H., Santella, R.M., Liaw, Y.F., and Chen, C.J. Effect of aflatoxin metabolism and DNA adduct formation on hepatocellular carcinoma among chronic hepatitis B carriers in Taiwan. J. Hepatology 27, 320-330, 1997.

Zhang, Y.J., Geacintov, N.E., and Santella, R.M. Development of monoclonal antibody recognizing benzo[c]phenanthrenediol epoxide-DNA adducts: application to immunohistochemical detection of DNA damage. Chem. Res. Tox. 10, 948-952, 1997.

Mathieu, A., Payne, J.F., Fancey, L.L., Santella, R.M., and Young, T.L. Polycyclic aromatic hydrocarbon DNA adducts in Beluga whales from the Artic. J. Toxicol. Environ. Health 51, 1-4, 1997.

Santella, R.M. DNA damage as an intermediate biomarker in intervention studies Exper. Med. Biol. 216, 166-171, 1997.

Sgambato, A. Zhang, Y.J., Santella, R.M., and Weinstein, I.B. Deregulated expression of p27Kip1 in human breast cancer. Clin. Cancer Res. 3, 1879-1887, 1997.

Lunn, R.M., Zhang, Y.J., Wang, L.Y., Chen, C.J., Lee, P.H., Lee, C.S., Tsai, W.Y., and Santella, R.M. P53 mutations, chronic hepatitis B virus infection, and aflatoxin exposure in hepatocellular carcinoma in Taiwan. Cancer Res. 57, 3471-3477, 1997.

Bowman, E.D., Rothman,N., Hackl,C., Santella, R.M. and Weston, A. Interindividual variation in the levels of certain urinary polycylic aromatic hydrocarbon metabolites following medicinal exposure to coal tar ointment. Biomarkers 2, 321-327, 1997.

Santella, R.M., Chen, C.J., Zhang, Y.J., Yu, M.W. and Wang, L.Y. Biological markers of aflatoxin B1 in hepatocellular cancer in Taiwan in Biomarkers Medical and Workplace Applications Mendelson, M.L., Mohr, L.C., and Peeters, J.P. editors, Joseph Henry Press Washington DC 355-364, 1998.

Mooney, L.A., Bell, D.A., Santella, R.M., Van Bennekum, A.M., Ottman, R., Paik, M., Blaner, W.S., Lucier, G.W., Covey, L., Young, T-L., Cooper, T.B., Glassman, A.H., Perera, F.P. Contribution of genetic and nutritional factors to DNA damage in heavy smokers. Carcinogensis 18, 101-107, 1997.

Gammon, M.D., Wolff, M.S., Neugut, A.I., Terry, M.B., Papadopoulos,K, Levin,B., Wang, Q, Santella, R.M. Temporal variation in chlorinated hydrocarbons in healthy women. Cancer Epidemiology, Biomarkers & Prevention. 6, 327-332, 1997.

Rousset, S., Nocentini, S., Santella, R.M., Moustacchi, E., 6,4,4'-Trimethylangelicin photoadduct immunodetection in DNA: induction and repair in fanconi anemia and normal human fibroblasts. J. Photochem. Photobiol. 38, 220-227, 1997.

Hsu, T-M., Zhang, Y-J., Santella, R.M. Immunoperoxidase quantitation of 4-aminobiphenyl- and polycyclic aromatic hydrocarbon-DNA adducts in exfoliated oral and urothelial cells of smokers and nonsmokers. Cancer Epi., Biomarkers & Prevention 6, 193-199, 1997.

1996

Motykiewicz, G., Perera, F.P., Santella, R.M., Hemminki, K., Seemayer, N.H., Chorazy, M. Assessment of cancer hazard from environmental pollution in Silesia. Toxicology Let., 88, 169-173, 1996.

Gammon, M.D., Wolff, M.S., Neugut, A.I., Terry, M.B., Britton, J.A., Greenebaum, E., Hibshoosh, H., Levin, B., Wang, Q., Santella, R.M., Treatment for breast cancer and blood levels of chlorinated hydrocarbons. Cancer Epidemiology, Biomarkers & Prevention 5, 457-459. 1996.

Mumford, J.L., Williams, K., Wilcosky, T.C., Everson, R.B., Young, T.L., Santella, R.M., A sensitive color ELISA for detecting polycyclic aromatic hydrocarbon-DNA adducts in human tissues. Mutation Research, 359, 171-177, 1996.

Wang, L-Y., Hatch, M., Chen, C-J., Levin, B., You, S-L., Wu, M-H., Wu, W-P., Wang, L-W., Wang, Q., Huang, G-T., Yang, P-M., Lee, H-S., Santella, R.M. Aflatoxin exposure and the risk of hepatocellular carcinoma in Taiwan. Int. J. Cancer, 67, 620-625, 1996.

Burgeot, T., Bocquene, G., Porte, C., Dimeet, J., Santella, R.M., Garcia de la Parra, L.M., Pihol-Leszkowicz, A., Raoux, C., Galgani, R.F. Bioindicators of pollutant exposure in the Northwestern Mediterranean Sea. Mar. Ecol. Prog. Ser. 131, 124-141, 1996.

Widlak, P., Gryzbowska, E., Hemminki, K., Santella, R.M., Chorazy, M. 32P postlabelling of bulky human DNA adducts enriched by different methods including immunoaffinity chromatography. Chem.-Biol. Interactions 99, 99-107, 1996.

Curigliano, G., Zhang, Y-J., Wang, L-Y., Flamini, G., Alcini, A., Ratto, C, Giustacchini, M., Alcini, E., Cittadini, A., Santella, R.M. Immunohistochemical quantitation of 4-aminobiphenyl-DNA adducts and p53 nuclear overexpression in T1 bladder cancer of smokers and nonsmokers. Carcinogenesis 17, 911-916, 1996.

Chen, C-J., Yu, M-W., Liaw, Y-F., Wang, L-W., Chiamprasert, S., Matin, F., Hirvonen, A., Bell, D.A., Santella, R.M. Chronic hepatitis B carriers with null genotypes of glutathione S-transferase M1 and T1 who are exposed to aflatoxin are at increased risk of hepatocellular carcinoma. Amer. J. Human Genetic 59, 128-134. 1996.

Santella, R.M., Zhang, Y-J., Yarborough, A., Motykiewixz, G., Hsu, T-M., Lunn, R., Al-Atrash, J., Antisera to carcinogen-DNA adducts and their application in molecular epidemiology, Acta Medic Romana 34, 229-237, 1996.

Yarborough, A., Zhang, Y-J., Hsu, T-M., Santella, R.M. Immunoperoxidase detection of 8-hydroxydeoxyguanosine in aflatoxin B1-treated rat liver and human oral mucosal cells. Cancer Research 56, 683-688, 1996.

Chen, D-J., Wang, L-Y., Lu, S-N., Wu, M-H., You, S-L., Zhang,Y-J., Wang, L-W., Santella, R.M. Elevated aflatoxin exposure and increased risk of hepatocellular carcinoma. Hepatology 24, 38-42, 1996.

1995

Sgambato, A., Han, E.K-H, Zhang, Y-J, Moon, R.C., Santella, R.M., Weinstein, I.B. Deregulated expression of cyclin D1 and other cell cycle-related genes in carcinogen-induced rat mammary tumors. Carcinogenesis 16, 2193-2198, 1995.

Perera, F.P., Mooney, L.A., Dickey, C.P., Santella, R.M., Bell, D., Blaner, W., Tang, D., Whyatt, R.M. Molecular epidemiology in environmental carcinogenesis. Enviromental Health Perspectives 104, 441-443, 1996.

Zhou, P., Jiang, W., Zhang, Y-J., Kahn, S.M., Schieren, J.I., Santella, R.M., Weinstein, I.B. Antisense to cyclin D1 inhibits growth and reverses the transformed phenotype of human esophageal cancer cells. Oncogene, 11, 571-580, 1995.

Tang, D., Santella, R.M., Blackwood, A.M., Young, T-L., Mayer, J., Jaretzki, A., Grantham, S., Tsai, W-Y., Perera, F.P. A molecular epidemiological case-control study of lung cancer. Cancer Epidemiology, Biomarkers & prevention 4, 341-346, 1995.

Hsu, T.M., Liu, T.M., Amin, S., Geacintov, N.E., Santella, R.M. Determination of stereospecificity of benzo[a]pyrene diol epoxide-DNA antisera with site-specifically modified oliogonucleotides. Carcinogenesis 16, 2263-2265, 1995.

Yu, M-W, Yarborough, A.G., Chiamprasert, S., Santella, R.M., Liaw, Y.-F., Chen, C.-J. Cytochrome P-450 2E1 and glutathione S-transferase M1 polymorphisms and susceptibility to hepatocellular carcinoma. Gastroenterology, 109, 1266-1273, 1995.

Mooney, L.A., Santella, R.M., Covey, L., Jeffrey, A.M., Bigbee, W., Randall, M.C., Cooper, T.B., Ottman, R., Tsai, W-Y, Wazneh, L., Glassman, A.H., Young, T-L, Perera, F.P. Decline of DNA damage and other biomarkers in peripheral blood following smoking cessation. Cancer Epidemiology, Biomarkers, and Prevention 4, 579-690, 1995.

Han, E.K-H., Sgambato, A., Jiang, W., Zhang, Y.J., Santella, R.M., Doki, Y., Cacace, A.M., Schieren, I., Weinstein,I.B. Stable overexpression of cyclin D1 in a human mammary epithelial cell line prolongs the S-phase and inhibits growth. Oncogene 10, 953-961, 1995.

Motykiewicz, G., Malusecka, E., Grzybowska, E., Chorazy, M., Zhang, Y-J, Perera, F.P., Santella, R.M. Immunohistochemical quantitation of polycyclic aromatic hydrocarbon-DNA adducts in human lymphocytes. Cancer Research, 55, 1417-1422, 1995.

Al-Atrash, J., Zhang, Y-J., Kin, D., Kadlubar, F.F., Santella, R.M. Quantitative immuno-histochemical analysis of 4-Aminobiphenyl-DNA in cultured cells and mice: Comparison to gas chromatography/mass spectroscopy analysis. Chemical Research in Toxicology, 8, 747-754, 1995.

Yin, B., Whyatt, R.M., Perera, F.P., Randall, R.C., Cooper, T., Santella, R.M. Determination of 8-hydroxydeoxyguanosine by an immunoaffinity chromatography-monoclonal antibody-based ELISA. Free Radical Biology & Medicine, 18, 1023-1032, 1995.

Zhang, Y.J., Hsu, T.M., Santella, R.M. Immunoperoxidase detection of polycyclic aromatic hydrocarbon-DNA adduct in oral mucosa cells of smokers and nonsmokers. Cancer Epidemiology, Biomarkers & Prevention 4, 133-138, 1995.

Santella, R.M. The Epidemiology of primary hepatocellular cancer. New Perspectives in Cancer Diagnoses and Management, 3, 3-14. 1995.

Santella, R.M., Perera, F.P., Young, T.L., Zhang, Y-J, Chiamprasert, S., Deliang, T., Wang, L.W., Beachman, A., Lin, J-H, and DeLeo, V.A. Polycyclic aromatic hydrocarbon DNA and protein adducts in coal tar treated patients and controls and their relationship to glutathione-S-transferase genotype. Mut Research, 334, 117-124. 1995.

Weinstein, I.B., Carothers, A.M., Santella, R.M., Perera, F. Molecular Mechanisms of mutagenesis and multistage carcinogenesis. In: The Molecular Basis of Cancer, Mendelsohn, Howley, Liotta and Israel, (Eds.), 1995.

Weinstein, I.B., Santella, R.M., Perera, F.P. The molecular biology and molecular epidemiology of cancer. In: The Science and Practice of Cancer Prevention and Control, Greenwald, P., Kramer, B.S. and Weed, D.L. (Eds.), Marcel-Dekker, 1995.

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